PLK2

PLK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I5M, 4I5P, 4I6B, 4I6F, 4I6H, 4RS6, 4XB0
Identifiers
Aliases	PLK2, SNK, hPlk2, hSNK, polo like kinase 2
External IDs	OMIM: 607023; MGI: 1099790; HomoloGene: 21317; GeneCards: PLK2; OMA:PLK2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	58,460,139 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	110,537,378 bp
RNA expression pattern
	Top expressed in
	spleen; ; apex of heart; ; canal of the cervix; ; ectocervix; ; islet of Langerhans; ; epithelium of colon; ; skin of abdomen; ; Achilles tendon; ; gallbladder; ; tibial nerve;
	Top expressed in
	CA3 field; ; Region I of hippocampus proper; ; perirhinal cortex; ; entorhinal cortex; ; primary motor cortex; ; primary visual cortex; ; olfactory tubercle; ; choroid plexus of fourth ventricle; ; superior frontal gyrus; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein-containing complex binding; signal transducer activity; ATP-dependent protein binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; centrosome; cell projection; intracellular anatomical structure; dendrite; centriole; chromatin; cytoskeleton; cytosol;
Biological process	positive regulation of protein catabolic process; positive regulation of autophagy; phosphorylation; mitotic cell cycle checkpoint signaling; G1 phase; mitotic spindle organization; Rap protein signal transduction; regulation of centriole replication; negative regulation of apoptotic process; memory; regulation of synaptic plasticity; protein phosphorylation; peptidyl-serine phosphorylation; long-term depression; mitotic cell cycle; positive regulation of I-kappaB kinase/NF-kappaB signaling; Ras protein signal transduction; positive regulation of protein binding; negative regulation of dendritic spine development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; long-term potentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	10769
	20620
	ENSG00000145632
	ENSMUSG00000021701
	Q9NYY3
	P53351
	NM_006622; NM_001252226
	NM_152804
	NP_001239155; NP_006613
	NP_690017
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM]