PLK4

PLK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N19, 3COK, 4JXF, 4N7V, 4N7Z, 4N9J, 4YUR, 4YYP
Identifiers
Aliases	PLK4, SAK, STK18, MCCRP2, polo like kinase 4
External IDs	OMIM: 605031; MGI: 101783; HomoloGene: 7962; GeneCards: PLK4; OMA:PLK4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	127,899,224 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	40,771,318 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; sperm; ; testicle; ; left testis; ; right testis; ; bone marrow; ; bone marrow cells; ; rectum;
	Top expressed in
	zygote; ; tail of embryo; ; secondary oocyte; ; primary oocyte; ; genital tubercle; ; spermatid; ; spermatocyte; ; ventricular zone; ; epiblast; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; identical protein binding;
Cellular component	cytoplasm; centrosome; deuterosome; XY body; nucleolus; centriole; cleavage furrow; cytoskeleton; nucleus; cytosol;
Biological process	trophoblast giant cell differentiation; phosphorylation; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; G2/M transition of mitotic cell cycle; centriole replication; positive regulation of centriole replication; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	10733
	20873
	ENSG00000142731
	ENSMUSG00000025758
	O00444
	Q64702
	NM_001190799; NM_001190801; NM_014264
	NM_011495; NM_173169
	NP_001177728; NP_001177730; NP_055079
	NP_035625; NP_775261
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C. elegans homolog is zyg-1, and the Xenopus homolog is Plx4.