Phospholipid scramblase 1

PLSCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y2A
Identifiers
Aliases	PLSCR1, MMTRA1B, phospholipid scramblase 1
External IDs	OMIM: 604170; MGI: 893575; HomoloGene: 41418; GeneCards: PLSCR1; OMA:PLSCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	146,544,856 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	92,154,331 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; monocyte; ; caput epididymis; ; gallbladder; ; germinal epithelium; ; pericardium; ; mucosa of sigmoid colon; ; tail of epididymis; ; epithelium of nasopharynx; ; rectum;
	Top expressed in
	ileum; ; granulocyte; ; colon; ; yolk sac; ; jejunum; ; duodenum; ; proximal tubule; ; right kidney; ; lung; ; human kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phospholipid scramblase activity; DNA binding; calcium ion binding; CD4 receptor binding; SH3 domain binding; epidermal growth factor receptor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; enzyme binding;
Cellular component	integral component of membrane; cytosol; Golgi apparatus; membrane; extracellular matrix; plasma membrane; integral component of plasma membrane; nucleolus; membrane raft; extracellular exosome; nucleus; cytoplasm; perinuclear region of cytoplasm; collagen-containing extracellular matrix;
Biological process	phosphatidylserine biosynthetic process; regulation of mast cell activation; plasma membrane phospholipid scrambling; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; response to interferon-beta; regulation of Fc receptor mediated stimulatory signaling pathway; platelet activation; negative regulation of viral genome replication; positive regulation of gene expression; defense response to virus; acute-phase response; positive regulation of innate immune response; positive regulation of transcription by RNA polymerase II; apoptotic process; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5359
	22038
	ENSG00000188313
	ENSMUSG00000032369
	O15162
	Q9JJ00
	NM_021105; NM_001363872; NM_001363874
	NM_011636
	NP_066928; NP_001350801; NP_001350803
	NP_035766
	Wikidata
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Phospholipid scramblase 1 (PL scramblase 1) is an enzyme that in humans is encoded by the PLSCR1 gene.