PLXNA2

PLXNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q3J
Identifiers
Aliases	PLXNA2, OCT, PLXN2, plexin A2
External IDs	OMIM: 601054; MGI: 107684; HomoloGene: 56427; GeneCards: PLXNA2; OMA:PLXNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	208,244,384 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	194,499,177 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; body of pancreas; ; right lung; ; upper lobe of left lung; ; left ovary; ; right hemisphere of cerebellum; ; right ovary; ; postcentral gyrus; ; left coronary artery; ; right coronary artery;
	Top expressed in
	ganglionic eminence; ; Rostral migratory stream; ; medial ganglionic eminence; ; olfactory tubercle; ; hair follicle; ; lateral septal nucleus; ; nucleus accumbens; ; internal carotid artery; ; ventromedial nucleus; ; external carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; semaphorin receptor activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; semaphorin receptor complex; membrane; integral component of plasma membrane;
Biological process	somitogenesis; cell surface receptor signaling pathway; regulation of axon extension involved in axon guidance; cerebellar granule cell precursor tangential migration; branchiomotor neuron axon guidance; limb bud formation; neural tube development; semaphorin-plexin signaling pathway; signal transduction; pharyngeal system development; centrosome localization; regulation of cell migration; negative regulation of cell adhesion; regulation of cell shape; regulation of GTPase activity; positive regulation of axonogenesis; semaphorin-plexin signaling pathway involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5362
	18845
	ENSG00000076356
	ENSMUSG00000026640
	O75051
	P70207
	NM_025179
	NM_008882
	NP_079455
	NP_032908
	Wikidata
View/Edit Human	View/Edit Mouse

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

In some studies, the PLXNA2 gene is associated with schizophrenia. and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease