PM20D1

PM20D1
Identifiers
Aliases	PM20D1, Cps1, peptidase M20 domain containing 1
External IDs	OMIM: 617124; MGI: 2442939; HomoloGene: 65049; GeneCards: PM20D1; OMA:PM20D1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	205,850,132 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,749,211 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; body of pancreas; ; mucosa of ileum; ; skin of abdomen; ; granulocyte; ; nipple; ; islet of Langerhans; ; body of stomach;
	Top expressed in
	epithelium of small intestine; ; left lobe of liver; ; human kidney; ; proximal tubule; ; right kidney; ; jejunum; ; transitional epithelium of urinary bladder; ; intestinal villus; ; ileum; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metal ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; lyase activity;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	metabolism; proteolysis; negative regulation of neuron death; cellular amino acid metabolic process; amide biosynthetic process; cellular amide catabolic process; cellular lipid metabolic process; energy homeostasis; adaptive thermogenesis; regulation of oxidative phosphorylation uncoupler activity; nitrogen compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	148811
	212933
	ENSG00000162877
	ENSMUSG00000042251
	Q6GTS8
	Q8C165
	NM_152491
	NM_178079; NM_001357478
	NP_689704
	NP_835180; NP_001344407
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidase M20 domain containing 1 is a circulating enzyme which in humans is encoded by the PM20D1 gene. PM20D1 regulates bioactive N-acyl amide lipids and has been implicated in obesity, type 2 diabetes, pain, and Alzheimer's disease.