PMM1

PMM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FUC, 2FUE
Identifiers
Aliases	PMM1, Sec53, phosphomannomutase 1, PMMH-22, PMM 1
External IDs	OMIM: 601786; MGI: 1353418; HomoloGene: 90898; GeneCards: PMM1; OMA:PMM1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,589,871 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,845,131 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; body of stomach; ; right lobe of liver; ; nucleus accumbens; ; right frontal lobe; ; right adrenal gland; ; right lung; ; left adrenal gland; ; right adrenal cortex; ; cingulate gyrus;
	Top expressed in
	morula; ; morula; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; lateral hypothalamus; ; lateral geniculate nucleus; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphomannomutase activity; isomerase activity; protein binding; metal ion binding;
Cellular component	cytoplasm; soma; cytosol;
Biological process	mannose metabolic process; protein N-linked glycosylation; protein targeting to ER; GDP-mannose biosynthetic process; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	5372
	29858
	ENSG00000100417
	ENSMUSG00000022474
	Q92871
	O35621
	NM_002676
	NM_001282040; NM_001282041; NM_013872
	NP_002667
	NP_001268969; NP_001268970; NP_038900
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.

This enzyme has been extracted from the venom of the wasp species Polistes major major.