PMPCB

PMPCB
Identifiers
Aliases	PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52, peptidase, mitochondrial processing beta subunit, peptidase, mitochondrial processing subunit beta, MAS1
External IDs	OMIM: 603131; MGI: 1920328; HomoloGene: 3160; GeneCards: PMPCB; OMA:PMPCB - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	103,329,511 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	21,962,150 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; parotid gland; ; left adrenal gland; ; body of pancreas; ; left adrenal cortex; ; skin of thigh; ; gastric mucosa; ; skin of hip; ; rectum; ; left ovary;
	Top expressed in
	spermatid; ; spermatocyte; ; medullary collecting duct; ; renal corpuscle; ; cardiac muscle tissue of left ventricle; ; endocardial cushion; ; atrioventricular valve; ; right kidney; ; proximal tubule; ; interventricular septum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; catalytic activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; endopeptidase activity;
Cellular component	mitochondrial respiratory chain complex III; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; mitochondrial processing peptidase complex;
Biological process	mitochondrial electron transport, ubiquinol to cytochrome c; aerobic respiration; protein processing; proteolysis; mitochondrial calcium ion transmembrane transport; protein processing involved in protein targeting to mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	9512
	73078
	ENSG00000105819
	ENSMUSG00000029017
	O75439
	Q9CXT8
	NM_004279
	NM_028431
	NP_004270
	NP_082707
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial-processing peptidase subunit beta is an enzyme that in humans is encoded by the PMPCB gene. This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.