Mismatch repair endonuclease PMS2

PMS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EA6, 1H7S, 1H7U
Identifiers
Aliases	PMS2, HNPCC4, PMS2CL, PMSL2, MLH4, PMS1 homolog 2, mismatch repair system component, MMRCS4, PMS-2
External IDs	OMIM: 600259; MGI: 104288; HomoloGene: 133560; GeneCards: PMS2; OMA:PMS2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,009,106 bp
RNA expression pattern
	Top expressed in
	thymus; ; prefrontal cortex; ; testicle; ; superior frontal gyrus; ; corpus callosum; ; endometrium; ; ventricular zone; ; stromal cell of endometrium; ; cerebellar cortex; ; cerebellar hemisphere;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endonuclease activity; single-stranded DNA binding; ATP binding; mismatched DNA binding; DNA binding; MutSalpha complex binding; nuclease activity; protein binding; single base insertion or deletion binding; hydrolase activity; ATPase activity;
Cellular component	nucleus; microtubule cytoskeleton; nucleoplasm; MutLalpha complex; cytosol; plasma membrane; cytoplasmic ribonucleoprotein granule; mismatch repair complex;
Biological process	cellular response to DNA damage stimulus; somatic hypermutation of immunoglobulin genes; nucleic acid phosphodiester bond hydrolysis; DNA repair; DNA mismatch repair;
	Sources:Amigo / QuickGO
Orthologs
	5395
	18861
	ENSG00000122512
	ENSMUSG00000079109
	P54278
	P54279
NM_000535; NM_001322003; NM_001322004; NM_001322005; NM_001322006;
	NM_001322007; NM_001322008; NM_001322009; NM_001322010; NM_001322011; NM_001322012; NM_001322013; NM_001322014; NM_001322015
	NM_008886
NP_000526; NP_001308932; NP_001308933; NP_001308934; NP_001308935;
	NP_001308936; NP_001308937; NP_001308938; NP_001308939; NP_001308940; NP_001308941; NP_001308942; NP_001308943; NP_001308944
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mismatch repair endonuclease PMS2 (postmeiotic segregation increased 2) is an enzyme that in humans is encoded by the PMS2 gene.