PNPLA3

PNPLA3
Identifiers
Aliases	PNPLA3, ADPN, C22orf20, iPLA(2)epsilon, patatin like phospholipase domain containing 3
External IDs	OMIM: 609567; MGI: 2151796; HomoloGene: 11883; GeneCards: PNPLA3; OMA:PNPLA3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	43,964,488 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	84,071,437 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; buccal mucosa cell; ; right lobe of liver; ; secondary oocyte; ; tibia; ; skin of leg; ; vulva; ; testicle; ; skin of abdomen; ; middle temporal gyrus;
	Top expressed in
	white adipose tissue; ; neural layer of retina; ; zone of skin; ; esophagus; ; lens; ; lip; ; skeletal muscle tissue; ; left lung; ; quadriceps femoris muscle; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mono-olein transacylation activity; transferase activity; phospholipase A2 activity; acyltransferase activity; hydrolase activity; diolein transacylation activity; acylglycerol O-acyltransferase activity; lipoprotein lipase activity; triglyceride lipase activity; lysophosphatidic acid binding; long-chain fatty acyl-CoA binding; lysophosphatidic acid acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; cytoplasm; lipid droplet; membrane;
Biological process	lipid catabolic process; triglyceride biosynthetic process; metabolism; acylglycerol acyl-chain remodeling; lipid metabolism; triglyceride catabolic process; triglyceride acyl-chain remodeling; lipid homeostasis; long-chain fatty acid metabolic process; glycerophospholipid metabolic process; phosphatidic acid biosynthetic process; lipid droplet organization; phospholipid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	80339
	116939
	ENSG00000100344
	ENSMUSG00000041653
	Q9NST1
	Q91WW7
	NM_025225
	NM_054088
	NP_079501
	NP_473429; NP_001395268; NP_001395269; NP_001395270; NP_001395271
	Wikidata
View/Edit Human	View/Edit Mouse

Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.