Neuropathy target esterase

PNPLA6
Identifiers
Aliases	PNPLA6, BNHS, NTE, NTEMND, SPG39, iPLA2delta, sws, LNMS, OMCS, patatin like phospholipase domain containing 6
External IDs	OMIM: 603197; MGI: 1354723; HomoloGene: 21333; GeneCards: PNPLA6; OMA:PNPLA6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,561,764 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,594,267 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; upper lobe of left lung; ; right frontal lobe; ; anterior pituitary; ; mucosa of transverse colon; ; right lung; ; right testis; ; spleen; ; left testis; ; apex of heart;
	Top expressed in
	neural layer of retina; ; epithelium of small intestine; ; superior frontal gyrus; ; gastrula; ; primary visual cortex; ; vestibular membrane of cochlear duct; ; right kidney; ; lens; ; epiblast; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; lysophospholipase activity;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; endoplasmic reticulum membrane;
Biological process	lipid catabolic process; metabolism; phosphatidylcholine metabolic process; developmental process; lipid metabolism; glycerophospholipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10908
	50767
	ENSG00000032444
	ENSMUSG00000004565
	Q8IY17
	Q3TRM4
	NM_006702; NM_001166111; NM_001166112; NM_001166113; NM_001166114
NM_001122818; NM_015801; NM_001359121; NM_001359122; NM_001359123;
	NM_001359124; NM_001378951; NM_001378952; NM_001378953; NM_001378954; NM_001378955
	NP_001159583; NP_001159584; NP_001159585; NP_001159586; NP_006693
NP_001116290; NP_056616; NP_001346050; NP_001346051; NP_001346052;
	NP_001346053; NP_001365880; NP_001365881; NP_001365882; NP_001365883; NP_001365884
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropathy target esterase, also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), is an esterase enzyme that in humans is encoded by the PNPLA6 gene.

Neuropathy target esterase is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells.