POGZ

POGZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E72, 2N3A
Identifiers
Aliases	POGZ, ZNF280E, ZNF635, ZNF635m, MRD37, WHSUS, pogo transposable element with ZNF domain, pogo transposable element derived with ZNF domain
External IDs	OMIM: 614787; MGI: 2442117; HomoloGene: 9022; GeneCards: POGZ; OMA:POGZ - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,459,494 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,789,637 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; buccal mucosa cell; ; sural nerve; ; left ovary; ; pituitary gland; ; right ovary; ; anterior pituitary; ; ganglionic eminence; ; right lobe of thyroid gland;
	Top expressed in
	tail of embryo; ; Gonadal ridge; ; genital tubercle; ; otic vesicle; ; hand; ; Rostral migratory stream; ; cumulus cell; ; ciliary body; ; primitive streak; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	cytoplasm; chromosome; nucleus; nucleoplasm; cytosol; histone methyltransferase complex;
Biological process	kinetochore assembly; cell cycle; mitotic sister chromatid cohesion; cell division; regulation of transcription by RNA polymerase II; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	23126
	229584
	ENSG00000143442
	ENSMUSG00000038902
	Q7Z3K3
	Q8BZH4
	NM_001194937; NM_001194938; NM_015100; NM_145796; NM_207171
	NM_001165948; NM_172683; NM_001368811; NM_001368812
	NP_001181866; NP_001181867; NP_055915; NP_665739; NP_997054
	NP_001159420; NP_766271; NP_001355740; NP_001355741
	Wikidata
View/Edit Human	View/Edit Mouse

Pogo transposable element with ZNF domain is a protein that in humans is encoded by the POGZ gene.

The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus.

This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.

The CHAMP1 protein complex consisting of CHAMP1, POGZ and HPIα promotes heterochromatin assembly at multiple chromosomal sites, and also promotes homology-directed DNA repair of DNA double-strand breaks in these regions.