POLE3

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,410,675 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,443,305 bp
RNA expression pattern
	Top expressed in
	gonad; ; gastrocnemius muscle; ; granulocyte; ; monocyte; ; human penis; ; ganglionic eminence; ; muscle of thigh; ; rectum; ; ventricular zone; ; bone marrow;
	Top expressed in
	spermatocyte; ; ventricular zone; ; yolk sac; ; secondary oocyte; ; zygote; ; fetal liver hematopoietic progenitor cell; ; seminiferous tubule; ; morula; ; molar; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; protein heterodimerization activity; histone acetyltransferase activity;
Cellular component	epsilon DNA polymerase complex; nucleus; nucleoplasm;
Biological process	DNA replication; histone H3 acetylation; DNA biosynthetic process; G1/S transition of mitotic cell cycle; cellular response to DNA damage stimulus; CENP-A containing chromatin assembly; cellular response to gamma radiation; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	54107
	59001
	ENSG00000148229
	ENSMUSG00000028394
	Q9NRF9
	Q9JKP7
	NM_001278255; NM_017443
	NM_021498
	NP_001265184; NP_059139
	NP_067473
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]