POLE (gene)

POLE
Identifiers
Aliases	POLE, CRCS12, FILS, POLE1, polymerase (DNA) epsilon, catalytic subunit, DNA polymerase epsilon, catalytic subunit, IMAGEI
External IDs	OMIM: 174762; MGI: 1196391; HomoloGene: 4539; GeneCards: POLE; OMA:POLE - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,687,376 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,485,340 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right testis; ; left testis; ; sural nerve; ; ventricular zone; ; spleen; ; skin of abdomen; ; skin of leg; ; ganglionic eminence; ; right lobe of liver;
	Top expressed in
	otic vesicle; ; otic placode; ; saccule; ; tail of embryo; ; internal carotid artery; ; epiblast; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; DNA binding; 4 iron, 4 sulfur cluster binding; nucleotidyltransferase activity; iron-sulfur cluster binding; zinc ion binding; chromatin binding; metal ion binding; nucleic acid binding; DNA-directed DNA polymerase activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; protein binding;
Cellular component	plasma membrane; nucleoplasm; nucleus; epsilon DNA polymerase complex;
Biological process	nucleotide-excision repair, DNA gap filling; DNA synthesis involved in DNA repair; DNA biosynthetic process; embryonic organ development; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; base-excision repair, gap-filling; DNA repair; DNA replication; leading strand elongation; DNA replication proofreading; G1/S transition of mitotic cell cycle; mitotic cell cycle; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	5426
	18973
	ENSG00000177084
	ENSMUSG00000007080
	Q07864
	Q9WVF7
	NM_006231
	NM_011132
	NP_006222
	NP_035262
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene. It is the central catalytic subunit of DNA polymerase epsilon.