POLG2

POLG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G4C, 3IKL, 3IKM, 4ZTU, 4ZTZ, 5C53, 5C51, 5C52
Identifiers
Aliases	POLG2, HP55, MTPOLB, PEOA4, POLB, POLG-BETA, POLGB, polymerase (DNA) gamma 2, accessory subunit, DNA polymerase gamma 2, accessory subunit, MTDPS16, MTDPS16A, MTDPS16B
External IDs	OMIM: 604983; MGI: 1354947; HomoloGene: 5221; GeneCards: POLG2; OMA:POLG2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,497,054 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,670,363 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; left testis; ; right testis; ; left ovary; ; right ovary; ; right uterine tube; ; granulocyte; ; monocyte; ; lymph node; ; spleen;
	Top expressed in
	retinal pigment epithelium; ; epithelium of lens; ; granulocyte; ; Paneth cell; ; neural layer of retina; ; primitive streak; ; left lobe of liver; ; fossa; ; condyle; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; protein binding; glycine-tRNA ligase activity; identical protein binding; DNA-directed DNA polymerase activity;
Cellular component	mitochondrial chromosome; mitochondrial matrix; mitochondrion; mitochondrial nucleoid; cytoplasm;
Biological process	DNA-dependent DNA replication; mitochondrial DNA metabolic process; mitochondrion organization; in utero embryonic development; DNA replication; respiratory electron transport chain; mitochondrion morphogenesis; DNA repair; DNA biosynthetic process; mitochondrial glycyl-tRNA aminoacylation; mitochondrial DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	11232
	50776
	ENSG00000256525
	ENSMUSG00000020718
	Q9UHN1
	Q9QZM2
	NM_007215
	NM_015810; NM_001353435
	NP_009146
	NP_056625; NP_001340364
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase subunit gamma-2, mitochondrial is a protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.