DNA polymerase nu

POLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XVI, 4XVK, 4XVL, 4XVM
Identifiers
Aliases	POLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDs	OMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,242,121 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,326,792 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; putamen; ; nucleus accumbens; ; right frontal lobe; ; Brodmann area 9; ; testicle; ; anterior cingulate cortex; ; left testis; ; right testis; ; cerebellar hemisphere;
	Top expressed in
	spermatocyte; ; spermatid; ; brown adipose tissue; ; seminiferous tubule; ; lens; ; lumbar subsegment of spinal cord; ; white adipose tissue; ; primary oocyte; ; zygote; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; 5'-3' exonuclease activity; protein binding; cyclin binding; DNA-directed DNA polymerase activity; nucleic acid binding;
Cellular component	cytoplasm; nucleolus; nucleoplasm; nucleus;
Biological process	cellular response to DNA damage stimulus; DNA replication; double-strand break repair via homologous recombination; DNA repair; DNA-dependent DNA replication; interstrand cross-link repair; translesion synthesis; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	353497
	272158
	ENSG00000130997
	ENSMUSG00000045102
	Q7Z5Q5
	Q7TQ07
	NM_181808
	NM_001289803; NM_001289804; NM_181857
	NP_861524
	NP_001276732; NP_001276733; NP_862905
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. It is a family A DNA polymerase, considered to be the least effective of the polymerase enzymes. However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.