POLR2E

POLR2E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IY6, 5IY9, 5IY8, 5IYA, 5IYB, 5IY7, 5IYC, 5IYD
Identifiers
Aliases	POLR2E, RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E, RNA polymerase II subunit E, RNA polymerase II, I and III subunit E
External IDs	OMIM: 180664; MGI: 1913670; HomoloGene: 2018; GeneCards: POLR2E; OMA:POLR2E - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,095,380 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,875,629 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lobe of liver; ; prefrontal cortex; ; right frontal lobe; ; muscle of thigh; ; muscle layer of sigmoid colon; ; right adrenal gland; ; popliteal artery; ; abdominal fat; ; tibial arteries;
	Top expressed in
	yolk sac; ; embryo; ; morula; ; embryo; ; somite; ; blastocyst; ; epiblast; ; mandibular prominence; ; maxillary prominence; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II activity; RNA polymerase III activity; protein binding; RNA polymerase I activity; DNA-directed 5'-3' RNA polymerase activity;
Cellular component	cytosol; RNA polymerase I complex; RNA polymerase III complex; RNA polymerase II, core complex; nucleus; nucleoplasm;
Biological process	termination of RNA polymerase I transcription; mRNA splicing, via spliceosome; epigenetic maintenance of chromatin in transcription-competent conformation; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; viral process; transcription by RNA polymerase III; fibroblast growth factor receptor signaling pathway; snRNA transcription by RNA polymerase II; RNA metabolic process; regulation of gene silencing by miRNA; transcription, DNA-templated; transcription elongation from RNA polymerase I promoter; positive regulation of type I interferon production; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5434
	66420
	ENSG00000099817
	ENSMUSG00000004667
	P19388
	Q80UW8
	NM_002695; NM_001316323; NM_001316324
	NM_025554
	NP_001303252; NP_001303253; NP_002686
	NP_079830
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.