POLR2F

POLR2F
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QKL, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F
External IDs	OMIM: 604414; MGI: 1349393; HomoloGene: 7178; GeneCards: POLR2F; OMA:POLR2F - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,041,915 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,035,974 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; tibial nerve; ; tendon of biceps brachii; ; apex of heart; ; right lobe of liver; ; right auricle of heart; ; Amygdala; ; left ventricle; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	yolk sac; ; morula; ; morula; ; otic vesicle; ; medial ganglionic eminence; ; endothelial cell of lymphatic vessel; ; embryo; ; embryo; ; ventricular zone; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II activity; RNA polymerase III activity; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase I activity;
Cellular component	cytosol; nucleoplasm; RNA polymerase I complex; RNA polymerase III complex; RNA polymerase II, core complex; nucleus; fibrillar center;
Biological process	termination of RNA polymerase I transcription; mRNA splicing, via spliceosome; epigenetic maintenance of chromatin in transcription-competent conformation; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; transcription by RNA polymerase III; RNA metabolic process; regulation of gene silencing by miRNA; transcription, DNA-templated; transcription elongation from RNA polymerase I promoter; positive regulation of type I interferon production; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5435
	69833
	ENSG00000100142
	ENSMUSG00000033020
	P61218
	P61219
	NM_001301129; NM_001301130; NM_001301131; NM_021974; NM_001363825
	NM_027231
	NP_001288058; NP_001288059; NP_001288060; NP_068809; NP_001350754
	NP_081507
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.