POLR2G

POLR2G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C35, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDs	OMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,766,710 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,775,941 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; granulocyte; ; ganglionic eminence; ; C1 segment; ; right adrenal gland; ; right adrenal cortex; ; monocyte; ; stromal cell of endometrium; ; Descending thoracic aorta; ; rectum;
	Top expressed in
	medial ganglionic eminence; ; endocardial cushion; ; primary oocyte; ; facial motor nucleus; ; otic placode; ; atrioventricular junction; ; condyle; ; primitive streak; ; renal corpuscle; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; single-stranded DNA binding; single-stranded RNA binding; RNA binding; nucleic acid binding; translation initiation factor binding;
Cellular component	P-body; nucleoplasm; RNA polymerase II, core complex; nucleus;
Biological process	mRNA splicing, via spliceosome; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; positive regulation of translational initiation; nuclear-transcribed mRNA catabolic process, exonucleolytic; apoptotic process; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; RNA metabolic process; regulation of gene silencing by miRNA; transcription, DNA-templated; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5436
	67710
	ENSG00000168002
	ENSMUSG00000071662
	P62487
	P62488
	NM_002696
	NM_026329
	NP_002687
	NP_080605
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.