POLR2K

POLR2K
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2K, ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a, polymerase (RNA) II subunit K, RNA polymerase II subunit K, RNA polymerase II, I and III subunit K
External IDs	OMIM: 606033; MGI: 102725; HomoloGene: 86049; GeneCards: POLR2K; OMA:POLR2K - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	100,154,003 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	36,177,156 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Achilles tendon; ; tibial arteries; ; C1 segment; ; Brodmann area 9; ; left adrenal gland; ; right adrenal gland; ; rectum; ; ganglionic eminence; ; right adrenal cortex;
	Top expressed in
	quadriceps femoris muscle; ; morula; ; neural tube; ; yolk sac; ; ventricular zone; ; ganglionic eminence; ; embryo; ; proximal tubule; ; embryo; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; RNA polymerase II activity; metal ion binding; RNA polymerase III activity; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase I activity;
Cellular component	cytosol; nucleoplasm; RNA polymerase I complex; RNA polymerase III complex; RNA polymerase II, core complex; nucleus;
Biological process	termination of RNA polymerase I transcription; mRNA splicing, via spliceosome; epigenetic maintenance of chromatin in transcription-competent conformation; regulation of transcription by RNA polymerase I; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; RNA metabolic process; regulation of gene silencing by miRNA; transcription, DNA-templated; transcription elongation from RNA polymerase I promoter; positive regulation of type I interferon production; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5440
	17749
	ENSG00000147669
	ENSMUSG00000045996
	P53803
	Q63871
	NM_005034
	NM_001039368; NM_023127
	NP_005025
	NP_001034457; NP_075616
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene.

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases.