POLR3D

POLR3D
Identifiers
Aliases	POLR3D, BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D, RNA polymerase III subunit D, C53
External IDs	OMIM: 187280; MGI: 1914315; HomoloGene: 1303; GeneCards: POLR3D; OMA:POLR3D - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,254,601 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,680,887 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; Achilles tendon; ; gastrocnemius muscle; ; muscle of thigh; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; left testis; ; right testis;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; yolk sac; ; tail of embryo; ; ventricular zone; ; muscle of thigh; ; epiblast; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; DNA binding; chromatin binding; RNA polymerase III activity;
Cellular component	RNA polymerase III complex; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	positive regulation of interferon-beta production; immune system process; defense response to virus; positive regulation of innate immune response; transcription by RNA polymerase III; innate immune response; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	661
	67065
	ENSG00000168495
	ENSMUSG00000000776
	P05423
	Q91WD1
	NM_001722
	NM_001164082; NM_025945
	NP_001713
	NP_001157554; NP_080221
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.