POT1

POT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XJV, 3KJO, 3KJP
Identifiers
Aliases	POT1, CMM10, HGLM9, protection of telomeres 1
External IDs	OMIM: 606478; MGI: 2141503; HomoloGene: 32263; GeneCards: POT1; OMA:POT1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	124,929,983 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	25,809,245 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; germinal epithelium; ; Achilles tendon; ; sperm; ; Epithelium of choroid plexus; ; gastric mucosa; ; gonad; ; tibia; ; ventricular zone; ; retinal pigment epithelium;
	Top expressed in
	genital tubercle; ; tail of embryo; ; zygote; ; cumulus cell; ; Gonadal ridge; ; renal corpuscle; ; ventricular zone; ; primitive streak; ; epiblast; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; telomeric DNA binding; single-stranded telomeric DNA binding; DEAD/H-box RNA helicase binding; protein binding; G-rich strand telomeric DNA binding; telomerase inhibitor activity; G-rich single-stranded DNA binding; telomeric D-loop binding; telomeric G-quadruplex DNA binding; 8-hydroxy-2'-deoxyguanosine DNA binding;
Cellular component	nuclear telomere cap complex; nucleoplasm; chromosome; telomere; nucleus; shelterin complex;
Biological process	negative regulation of telomerase activity; DNA duplex unwinding; positive regulation of helicase activity; positive regulation of telomerase activity; establishment of protein localization to telomere; telomere assembly; positive regulation of DNA strand elongation; telomere maintenance; telomere capping; regulation of DNA helicase activity; positive regulation of DNA helicase activity; telomeric D-loop disassembly; telomere maintenance via telomerase; regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	25913
	101185
	ENSG00000128513
	ENSMUSG00000029676
	Q9NUX5
	Q91WC1
	NM_001042594; NM_015450
	NM_133931
	NP_001036059; NP_056265; NP_001036059.1
	NP_598692
	Wikidata
View/Edit Human	View/Edit Mouse

Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.