POU2AF1

POU2AF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CQT
Identifiers
Aliases	POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDs	OMIM: 601206; MGI: 105086; HomoloGene: 4543; GeneCards: POU2AF1; OMA:POU2AF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,455,630 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	51,151,380 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; pylorus; ; cardia; ; spleen; ; lymph node; ; appendix; ; bronchial epithelial cell; ; tonsil; ; bone marrow cells; ; mucosa of ileum;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; submandibular gland; ; blood; ; tibiofemoral joint; ; female urethra; ; tunica adventitia of aorta; ; granulocyte; ; subcutaneous adipose tissue; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; protein binding; transcription coregulator activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; humoral immune response; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5450
	18985
	ENSG00000110777
	ENSMUSG00000032053
	Q16633
	Q64693
	NM_006235
	NM_011136
	NP_006226
	NP_035266
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1. BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36. The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas, as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.