POU3F4

POU3F4
Identifiers
Aliases	POU3F4, BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9, POU class 3 homeobox 4
External IDs	OMIM: 300039; MGI: 101894; HomoloGene: 260; GeneCards: POU3F4; OMA:POU3F4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	83,512,127 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	109,860,813 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; cingulate gyrus; ; Amygdala; ; anterior cingulate cortex; ; prefrontal cortex; ; Hypothalamus;
	Top expressed in
	Rostral migratory stream; ; medial ganglionic eminence; ; vestibular sensory epithelium; ; utricle; ; stria vascularis; ; vestibular membrane of cochlear duct; ; lumbar subsegment of spinal cord; ; hair; ; ventricular zone; ; cochlea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; minor groove of adenine-thymine-rich DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of mesenchymal cell apoptotic process; inner ear development; brain development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; hearing; cochlea morphogenesis; transcription, DNA-templated; forebrain neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5456
	18994
	ENSG00000196767
	ENSMUSG00000056854
	P49335
	P62515
	NM_000307
	NM_008901
	NP_000298
	NP_032927
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain, class 3, transcription factor 4 is a protein that in humans is encoded by the POU3F4 gene found on the X chromosome.

POU3F4 is involved in the patterning of the neural tube and both the paraventricular and supraoptic nuclei of the hypothalamus in the developing embryo. During development, POU3F4 is also expressed in the mesenchyme of the periotic bone surrounding the inner ear. A “knockout” mice model displayed that alteration to the POU3F4 gene interrupted this mesenchymal cell differentiation in the superior semicircular canal. The deformities observed in mice were similar to those in humans with X-linked non-syndromic deafness (DFN-3).