Amidophosphoribosyltransferase

PPAT
Identifiers
Aliases	PPAT, ATASE, GPAT, PRAT, phosphoribosyl pyrophosphate amidotransferase, Amidophosphoribosyltransferase
External IDs	OMIM: 172450; MGI: 2387203; HomoloGene: 68272; GeneCards: PPAT; OMA:PPAT - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	56,435,615 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,099,425 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; testicle; ; gonad; ; ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; body of pancreas; ; Achilles tendon; ; rectum; ; right adrenal cortex;
	Top expressed in
	primitive streak; ; morula; ; tail of embryo; ; somite; ; genital tubercle; ; epiblast; ; cumulus cell; ; embryo; ; embryo; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; transferase activity; catalytic activity; iron-sulfur cluster binding; glycosyltransferase activity; 4 iron, 4 sulfur cluster binding; amidophosphoribosyltransferase activity;
Cellular component	cytosol;
Biological process	glutamine metabolic process; 'de novo' IMP biosynthetic process; animal organ regeneration; cellular response to insulin stimulus; purine nucleobase biosynthetic process; maternal process involved in female pregnancy; metabolism; nucleoside metabolic process; kidney development; ribose phosphate metabolic process; purine nucleotide biosynthetic process; glutamine catabolic process; protein homotetramerization; lactation; purine ribonucleoside monophosphate biosynthetic process; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5471
	231327
	ENSG00000128059
	ENSMUSG00000029246
	Q06203
	Q8CIH9
	NM_002703
	NM_172146
	NP_002694
	NP_742158
	Wikidata
View/Edit Human	View/Edit Mouse

Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chain. This is the committing step in de novo purine synthesis. In humans it is encoded by the PPAT (phosphoribosyl pyrophosphate amidotransferase) gene. ATase is a member of the purine/pyrimidine phosphoribosyltransferase family.