PPIC

PPIC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ESL
Identifiers
Aliases	PPIC, CYPC, peptidylprolyl isomerase C
External IDs	OMIM: 123842; MGI: 97751; HomoloGene: 727; GeneCards: PPIC; OMA:PPIC - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	123,036,725 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	53,551,187 bp
RNA expression pattern
	Top expressed in
	tibia; ; tendon of biceps brachii; ; skin of hip; ; gums; ; gingival epithelium; ; pancreatic ductal cell; ; mucosa of sigmoid colon; ; periodontal fiber; ; palpebral conjunctiva; ; parotid gland;
	Top expressed in
	molar; ; calvaria; ; body of femur; ; dermis; ; endothelial cell of lymphatic vessel; ; efferent ductule; ; atrium; ; atrioventricular valve; ; left lung lobe; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cyclosporin A binding; protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding;
Cellular component	cytoplasm; extracellular exosome;
Biological process	protein folding; protein peptidyl-prolyl isomerization; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	5480
	19038
	ENSG00000168938
	ENSMUSG00000024538
	P45877
	P30412
	NM_000943
	NM_008908
	NP_000934
	NP_032934
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase C (PPIC) is an enzyme that in humans is encoded by the PPIC gene on chromosome 5. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPIC participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer.