PPIF

PPIF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BIT, 2BIU, 2Z6W, 3QYU, 3R49, 3R4G, 3R54, 3R56, 3R57, 3R59, 3RCF, 3RCG, 3RCI, 3RCK, 3RCL, 3RD9, 3RDA, 3RDB, 3RDC, 4J58, 4J59, 4J5A, 4J5B, 4J5C, 4J5D, 4J5E, 4O8H, 4O8I, 4XNC, 4ZSC, 4ZSD, 5A0E, 5CCS, 5CCN, 5CCQ, 5CBT, 5CCR
Identifiers
Aliases	PPIF, CYP3, CyP-M, Cyp-D, CypD, peptidylprolyl isomerase F
External IDs	OMIM: 604486; MGI: 2145814; HomoloGene: 38696; GeneCards: PPIF; OMA:PPIF - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,355,334 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	25,700,892 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; periodontal fiber; ; body of tongue; ; right lobe of liver; ; apex of heart; ; left ventricle; ; myocardium of left ventricle;
	Top expressed in
	pyloric antrum; ; interventricular septum; ; right ventricle; ; myocardium of ventricle; ; cardiac muscles; ; epithelium of stomach; ; lip; ; cardiac muscle tissue of left ventricle; ; mucous cell of stomach; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide binding; isomerase activity; protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding; unfolded protein binding;
Cellular component	mitochondrial proton-transporting ATP synthase complex; membrane; mitochondrial inner membrane; mitochondrion; mitochondrial matrix; mitochondrial permeability transition pore complex;
Biological process	regulation of apoptotic process; cellular response to calcium ion; programmed cell death; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of ATP-dependent activity; negative regulation of release of cytochrome c from mitochondria; negative regulation of apoptotic process; response to oxidative stress; regulation of necrotic cell death; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; response to ischemia; protein folding; cellular response to arsenic-containing substance; negative regulation of oxidative phosphorylation uncoupler activity; regulation of proton-transporting ATPase activity, rotational mechanism; positive regulation of release of cytochrome c from mitochondria; necroptosis; negative regulation of oxidative phosphorylation; cellular response to hydrogen peroxide; apoptotic process; apoptotic mitochondrial changes; regulation of mitochondrial membrane permeability; mitochondrial outer membrane permeabilization involved in programmed cell death; protein peptidyl-prolyl isomerization; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10105
	105675
	ENSG00000108179
	ENSMUSG00000021868
	P30405
	Q99KR7
	NM_005729
	NM_134084
	NP_005720
	NP_598845
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy. In addition, PPIF participates in inflammation, as well as in ischemic reperfusion injury, AIDS, and cancer.