PPIH

PPIH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MZW, 1QOI
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	OMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,676,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,177,743 bp
RNA expression pattern
	Top expressed in
	embryo; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; granulocyte; ; secondary oocyte; ; rectum; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; lymph node;
	Top expressed in
	ventricular zone; ; embryo; ; spermatocyte; ; embryo; ; yolk sac; ; morula; ; blastocyst; ; spermatid; ; genital tubercle; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonucleoprotein complex binding; isomerase activity; protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding; unfolded protein binding;
Cellular component	cytoplasm; nuclear speck; U4/U6 x U5 tri-snRNP complex; spliceosomal complex; nucleus; nucleoplasm; U4/U6 snRNP;
Biological process	mRNA splicing, via spliceosome; mRNA processing; positive regulation of viral genome replication; protein folding; RNA splicing; protein-containing complex assembly; protein peptidyl-prolyl isomerization; angiogenesis; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10465
	66101
	ENSG00000171960
	ENSMUSG00000060288
	O43447
	Q9D868
	NM_006347; NM_001330510
	NM_001110129; NM_001110130; NM_028677
	NP_001317439; NP_006338
	NP_001103599; NP_001103600; NP_082953
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.