PPM1A

PPM1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A6Q, 3FXJ, 3FXK, 3FXL, 3FXM, 3FXO, 4RA2, 4RAF, 4RAG
Identifiers
Aliases	PPM1A, PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
External IDs	OMIM: 606108; MGI: 99878; HomoloGene: 56428; GeneCards: PPM1A; OMA:PPM1A - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	60,299,087 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	72,799,819 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; biceps brachii; ; secondary oocyte; ; Skeletal muscle tissue of biceps brachii; ; jejunal mucosa; ; amniotic fluid; ; parotid gland; ; left testis; ; glutes;
	Top expressed in
	muscle of thigh; ; morula; ; substantia nigra; ; otic placode; ; spermatid; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; triceps brachii muscle; ; digastric muscle; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	R-SMAD binding; phosphoprotein phosphatase activity; manganese ion binding; protein serine/threonine phosphatase activity; calmodulin-dependent protein phosphatase activity; signal transducer activity; metal ion binding; catalytic activity; protein binding; cation binding; hydrolase activity; magnesium ion binding;
Cellular component	cytoplasm; membrane; nucleoplasm; nucleus; cytosol; plasma membrane;
Biological process	cellular response to transforming growth factor beta stimulus; peptidyl-threonine dephosphorylation; negative regulation of SMAD protein complex assembly; protein dephosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; N-terminal protein myristoylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5494
	19042
	ENSG00000100614
	ENSMUSG00000021096
	P35813
	P49443
	NM_021003; NM_177951; NM_177952
	NM_008910
	NP_066283; NP_808820; NP_808821
	NP_032936
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.