PPM1B

PPM1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P8E
Identifiers
Aliases	PPM1B, PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B
External IDs	OMIM: 603770; MGI: 101841; HomoloGene: 2027; GeneCards: PPM1B; OMA:PPM1B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	44,244,384 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,331,419 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; gastrocnemius muscle; ; biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; glutes;
	Top expressed in
	neural layer of retina; ; ankle; ; spermatid; ; muscle of thigh; ; digastric muscle; ; temporal muscle; ; saccule; ; sternocleidomastoid muscle; ; body of femur; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; magnesium ion binding; manganese ion binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; catalytic activity; cation binding; hydrolase activity; metal ion binding;
Cellular component	membrane; cytoplasm; nucleolus; cytosol; nucleus;
Biological process	protein dephosphorylation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of defense response to virus; N-terminal protein myristoylation; peptidyl-threonine dephosphorylation; negative regulation of interferon-beta production; negative regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	5495
	19043
	ENSG00000138032
	ENSMUSG00000061130
	O75688
	P36993
	NM_001033556; NM_001033557; NM_002706; NM_177968; NM_177969
	NM_001159496; NM_001159497; NM_001159498; NM_011151
	NP_001028729; NP_002697; NP_808907; NP_808908
	NP_001152968; NP_001152969; NP_001152970; NP_035281
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.