PPP1CA

PPP1CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E7A, 3E7B, 3EGG, 3EGH, 3HVQ, 3N5U, 3V4Y, 4G9J, 4MOV, 4MOY, 4MP0, 4XPN, 1FJM
Identifiers
Aliases	PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A, protein phosphatase 1 catalytic subunit alpha
External IDs	OMIM: 176875; MGI: 103016; HomoloGene: 105262; GeneCards: PPP1CA; OMA:PPP1CA - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,421,183 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,245,419 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; monocyte; ; spleen; ; thymus; ; apex of heart; ; blood; ; lymph node; ; mucosa of pharynx; ; human penis;
	Top expressed in
	striatum of neuraxis; ; tail of embryo; ; granulocyte; ; yolk sac; ; neural tube; ; thymus; ; Mesencephalon; ; white adipose tissue; ; epiblast; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; metal ion binding; protein binding; hydrolase activity; cadherin binding involved in cell-cell adhesion; protein serine/threonine phosphatase activity; phosphatase activity; protein phosphatase 1 binding; ribonucleoprotein complex binding; protein-containing complex binding;
Cellular component	cytoplasm; plasma membrane; nucleoplasm; PTW/PP1 phosphatase complex; nucleolus; extracellular exosome; nucleus; cytosol; protein phosphatase type 1 complex; glycogen granule; neuron projection; soma; dendritic spine; perikaryon; presynapse; postsynapse; glutamatergic synapse;
Biological process	regulation of canonical Wnt signaling pathway; negative regulation of protein binding; cell division; glycogen metabolic process; cell cycle; regulation of translational initiation by eIF2 alpha dephosphorylation; beta-catenin destruction complex disassembly; dephosphorylation; cell-cell adhesion; protein dephosphorylation; circadian regulation of gene expression; regulation of circadian rhythm; entrainment of circadian clock by photoperiod; carbohydrate metabolic process; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; response to lead ion; lung development; peptidyl-threonine dephosphorylation; branching morphogenesis of an epithelial tube; peptidyl-serine dephosphorylation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; viral process;
	Sources:Amigo / QuickGO
Orthologs
	5499
	19045
	ENSG00000172531
	ENSMUSG00000040385
	P62136
	P62137
	NM_206873; NM_001008709; NM_002708
	NM_031868
	NP_001008709; NP_002699; NP_996756
	NP_114074
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.