PPP1CB

PPP1CB
Identifiers
Aliases	PPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta, NSLH2, PPP1beta, PP1c, MP
External IDs	OMIM: 600590; MGI: 104871; HomoloGene: 37659; GeneCards: PPP1CB; OMA:PPP1CB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	28,802,940 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,674,777 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; buccal mucosa cell; ; ventricular zone; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; caput epididymis; ; ganglionic eminence;
	Top expressed in
	blood; ; Gonadal ridge; ; atrium; ; lobe of cerebellum; ; pineal gland; ; olfactory tubercle; ; ventral tegmental area; ; medial vestibular nucleus; ; cerebellar vermis; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; myosin phosphatase activity; phosphatase activity; protein serine/threonine phosphatase activity; metal ion binding; myosin-light-chain-phosphatase activity; protein binding; protein kinase binding; hydrolase activity;
Cellular component	cytoplasm; cytosol; focal adhesion; nucleoplasm; protein phosphatase type 1 complex; glycogen granule; PTW/PP1 phosphatase complex; nucleolus; extracellular exosome; nucleus; plasma membrane;
Biological process	rhythmic process; protein dephosphorylation; circadian regulation of gene expression; cell division; regulation of cell adhesion; G2/M transition of mitotic cell cycle; regulation of circadian rhythm; glycogen metabolic process; regulation of glycogen biosynthetic process; cell cycle; regulation of glycogen catabolic process; entrainment of circadian clock by photoperiod; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5500
	19046
	ENSG00000213639
	ENSMUSG00000014956
	P62140
	P62141
	NM_206877; NM_002709; NM_206876
	NM_172707
	NP_002700; NP_996759
	NP_766295
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.