PPP1R11

PPP1R11
Identifiers
Aliases	PPP1R11, HCG-V, HCGV, IPP3, TCTE5, TCTEX5, CFAP255, protein phosphatase 1 regulatory inhibitor subunit 11
External IDs	OMIM: 606670; MGI: 1923747; HomoloGene: 32520; GeneCards: PPP1R11; OMA:PPP1R11 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,070,333 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	37,262,633 bp
RNA expression pattern
	Top expressed in
	rectum; ; superior frontal gyrus; ; smooth muscle tissue; ; mucosa of transverse colon; ; granulocyte; ; duodenum; ; blood; ; epithelium of colon; ; primary visual cortex; ; body of stomach;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; interventricular septum; ; neural layer of retina; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst; ; muscle of thigh; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity; protein binding; protein phosphatase 1 binding; protein serine/threonine phosphatase inhibitor activity; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytoplasm; protein phosphatase type 1 complex; nucleus;
Biological process	negative regulation of phosphoprotein phosphatase activity; defense response to Gram-positive bacterium; protein ubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	6992
	76497
ENSG00000234058; ENSG00000236560; ENSG00000237829; ENSG00000204619; ENSG00000237403;
	ENSG00000233314; ENSG00000206501; ENSG00000227720
	ENSMUSG00000036398
	O60927
	Q8K1L5
	NM_021959; NM_170781
	NM_029632
	NP_068778; NP_068778.1
	NP_083908
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.

The gene is located within the major histocompatibility complex class I region on chromosome 6.