PPP1R12B

PPP1R12B
Identifiers
Aliases	PPP1R12B, MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B
External IDs	OMIM: 603768; MGI: 1916417; HomoloGene: 136757; GeneCards: PPP1R12B; OMA:PPP1R12B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,592,706 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,883,680 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; myocardium of left ventricle; ; right coronary artery; ; cardiac muscle tissue of right atrium; ; right ventricle; ; popliteal artery; ; tibial arteries; ; tail of epididymis; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	Rostral migratory stream; ; ascending aorta; ; muscle of thigh; ; aortic valve; ; soleus muscle; ; extraocular muscle; ; digastric muscle; ; temporal muscle; ; vastus lateralis muscle; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity; protein binding; protein kinase binding; phosphatase regulator activity; enzyme inhibitor activity;
Cellular component	cytoplasm; cytosol; A band; Z discdkac; nucleoplasm; cytoskeleton;
Biological process	regulation of muscle contraction; positive regulation of catalytic activity; signal transduction; regulation of catalytic activity; negative regulation of catalytic activity; G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	4660
	329251
	ENSG00000077157
	ENSMUSG00000073557
	O60237
	Q8BG95
NM_001167857; NM_001167858; NM_001197131; NM_002481; NM_032103;
	NM_032104; NM_032105; NM_001331029
	NM_001081307; NM_001368827; NM_001368829
NP_001161329; NP_001161330; NP_001184060; NP_001317958; NP_002472;
	NP_115286; NP_115287
	NP_001074776; NP_001355756; NP_001355758
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.