PPP1R13B

PPP1R13B
Identifiers
Aliases	PPP1R13B, ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B
External IDs	OMIM: 606455; MGI: 1336199; HomoloGene: 9090; GeneCards: PPP1R13B; OMA:PPP1R13B - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,847,575 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,874,544 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart; ; right hemisphere of cerebellum; ; left testis; ; right testis; ; right auricle of heart; ; left ventricle; ; Brodmann area 10; ; right frontal lobe;
	Top expressed in
	retinal pigment epithelium; ; gastrula; ; decidua; ; otolith organ; ; renal corpuscle; ; utricle; ; lacrimal gland; ; facial motor nucleus; ; ciliary body; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; protein binding; p53 binding;
Cellular component	plasma membrane; nucleus; mitochondrion; nucleoplasm; cytoplasm; cytosol; perinuclear region of cytoplasm;
Biological process	negative regulation of cell cycle; intrinsic apoptotic signaling pathway by p53 class mediator; apoptotic process; regulation of signal transduction by p53 class mediator; regulation of apoptotic process; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of neuron death;
	Sources:Amigo / QuickGO
Orthologs
	23368
	21981
	ENSG00000088808
	ENSMUSG00000021285
	Q96KQ4
	Q62415
	NM_015316
	NM_011625
	NP_056131
	NP_035755
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.