PPP1R8

PPP1R8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V4Y
Identifiers
Aliases	PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
External IDs	OMIM: 602636; MGI: 2140494; HomoloGene: 8555; GeneCards: PPP1R8; OMA:PPP1R8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,851,676 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,570,480 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ventricular zone; ; islet of Langerhans; ; ganglionic eminence; ; stromal cell of endometrium; ; smooth muscle tissue; ; lymph node; ; C1 segment; ; granulocyte; ; mucosa of sigmoid colon;
	Top expressed in
	somite; ; mandibular prominence; ; maxillary prominence; ; epiblast; ; medial ganglionic eminence; ; abdominal wall; ; hand; ; otic vesicle; ; condyle; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase inhibitor activity; DNA binding; protein binding; RNA binding; protein phosphatase inhibitor activity; nuclease activity; endonuclease activity; ribonuclease E activity; hydrolase activity; mRNA binding; protein phosphatase regulator activity;
Cellular component	cytoplasm; nuclear speck; nucleoplasm; spliceosomal complex; nucleus;
Biological process	regulation of transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; mRNA processing; RNA catabolic process; transcription, DNA-templated; RNA splicing; cell population proliferation; RNA phosphodiester bond hydrolysis; negative regulation of protein dephosphorylation; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity; production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologs
	5511
	100336
	ENSG00000117751
	ENSMUSG00000028882
	Q12972
	Q8R3G1
	NM_138558; NM_002713; NM_014110
	NM_001290725; NM_146154; NM_001355198; NM_001355199
	NP_002704; NP_054829; NP_612568
	NP_001277654; NP_666266; NP_001342127; NP_001342128
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.