PPP1R9B

PPP1R9B
Identifiers
Aliases	PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B
External IDs	OMIM: 603325; MGI: 2387581; HomoloGene: 32787; GeneCards: PPP1R9B; OMA:PPP1R9B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,150,677 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,897,725 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; granulocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; monocyte; ; right frontal lobe; ; Amygdala; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; neural layer of retina; ; granulocyte; ; lip; ; ventricular zone; ; cerebellar cortex; ; esophagus; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 1 binding; protein binding; protein phosphatase inhibitor activity; actin binding; actin filament binding;
Cellular component	cytoplasm; cell projection; membrane; filopodium; adherens junction; plasma membrane; dendritic spine; synapse; nucleoplasm; ruffle membrane; cell junction; protein phosphatase type 1 complex; cytoskeleton; nucleus; lamellipodium; postsynaptic density; actin cytoskeleton; dendrite;
Biological process	cell differentiation; regulation of opioid receptor signaling pathway; filopodium assembly; regulation of cell growth by extracellular stimulus; modulation of chemical synaptic transmission; nervous system development; multicellular organism development; regulation of cell population proliferation; negative regulation of cell growth; RNA splicing; cellular response to morphine; cell migration; regulation of exit from mitosis; negative regulation of phosphoprotein phosphatase activity; actin filament organization; calcium-mediated signaling; neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	84687
	217124
	ENSG00000108819
	ENSMUSG00000038976
	Q96SB3
	Q6R891
	NM_032595
	NM_172261
	NP_115984
	NP_758465
	Wikidata
View/Edit Human	View/Edit Mouse

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]