PPP2R1A

PPP2R1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W
Identifiers
Aliases	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
External IDs	OMIM: 605983; MGI: 1926334; HomoloGene: 68559; GeneCards: PPP2R1A; OMA:PPP2R1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	52,229,518 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	21,186,178 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; ganglionic eminence; ; right frontal lobe; ; right hemisphere of cerebellum; ; ventricular zone; ; right adrenal cortex; ; prefrontal cortex; ; cingulate gyrus; ; right auricle of heart; ; left adrenal cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; motor neuron; ; facial motor nucleus; ; primitive streak; ; endothelial cell of lymphatic vessel; ; anterior horn of spinal cord; ; vas deferens; ; ciliary body; ; medial ganglionic eminence; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; protein heterodimerization activity; protein phosphatase regulator activity; protein antigen binding;
Cellular component	cytoplasm; cytosol; microtubule cytoskeleton; protein phosphatase type 2A complex; chromosome; mitochondrion; chromosome, centromeric region; extracellular exosome; nucleus; plasma membrane; membrane; lateral plasma membrane; dendrite; cell projection; synapse; glutamatergic synapse;
Biological process	apoptotic process; regulation of meiotic cell cycle process involved in oocyte maturation; meiotic sister chromatid cohesion, centromeric; regulation of transcription, DNA-templated; ceramide metabolic process; regulation of DNA replication; chromosome segregation; protein dephosphorylation; meiotic spindle elongation; female meiotic nuclear division; response to organic substance; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; peptidyl-serine dephosphorylation; regulation of Wnt signaling pathway; regulation of cell adhesion; G2/M transition of mitotic cell cycle; negative regulation of cell growth; RNA splicing; regulation of cell differentiation; regulation of growth; mitotic nuclear membrane reassembly; mitotic sister chromatid separation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; second-messenger-mediated signaling; ciliary basal body-plasma membrane docking; negative regulation of tyrosine phosphorylation of STAT protein; regulation of G2/M transition of mitotic cell cycle; regulation of phosphoprotein phosphatase activity; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	5518
	51792
	ENSG00000105568
	ENSMUSG00000007564
	P30153
	Q76MZ3
	NM_014225; NM_001363656
	NM_016891
	NP_055040; NP_001350585; NP_055040.2
	NP_058587
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).