PPP2R2B

PPP2R2B
Identifiers
Aliases	PPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12, protein phosphatase 2 regulatory subunit Bbeta
External IDs	OMIM: 604325; MGI: 1920180; HomoloGene: 55833; GeneCards: PPP2R2B; OMA:PPP2R2B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	147,084,784 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	43,216,192 bp
RNA expression pattern
	Top expressed in
	sperm; ; ganglionic eminence; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; Brodmann area 23; ; putamen; ; endothelial cell; ; primary visual cortex; ; dorsolateral prefrontal cortex;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; neural layer of retina; ; CA3 field; ; primary motor cortex; ; anterior amygdaloid area; ; visual cortex; ; primary visual cortex; ; central gray substance of midbrain; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein serine/threonine phosphatase activity; protein phosphatase regulator activity;
Cellular component	cytoplasm; mitochondrial outer membrane; cytoskeleton; membrane; mitochondrion; protein phosphatase type 2A complex; cytosol;
Biological process	apoptotic process; mitotic cell cycle; peptidyl-serine dephosphorylation; developmental process; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	5521
	72930
	ENSG00000156475
	ENSMUSG00000024500
	Q00005
	Q6ZWR4
NM_001271899; NM_001271900; NM_001271948; NM_181674; NM_181675;
	NM_181676; NM_181677; NM_181678
	NM_027531; NM_028392
NP_001258828; NP_001258829; NP_001258877; NP_858060; NP_858061;
	NP_858062; NP_858063; NP_858064
	NP_082668; NP_081807; NP_001390894
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.