PPRC1

PPRC1
Identifiers
Aliases	PPRC1, PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1, PPARG related coactivator 1
External IDs	OMIM: 617462; MGI: 2385096; HomoloGene: 9006; GeneCards: PPRC1; OMA:PPRC1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,150,333 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,061,354 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; oocyte; ; skin of abdomen; ; upper lobe of left lung; ; left ovary; ; right ovary; ; anterior pituitary; ; secondary oocyte; ; skin of leg; ; gonad;
	Top expressed in
	otic placode; ; epiblast; ; otic vesicle; ; tail of embryo; ; saccule; ; primitive streak; ; Gonadal ridge; ; human fetus; ; morula; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclear receptor coactivator activity; nucleic acid binding; transcription coregulator activity; RNA binding; transcription factor binding;
Cellular component	nucleus; nucleoplasm;
Biological process	positive regulation of DNA-binding transcription factor activity; mitochondrion organization; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	23082
	226169
	ENSG00000148840
	ENSMUSG00000055491
	Q5VV67
	Q6NZN1
	NM_001288727; NM_001288728; NM_015062
	NM_001081214; NM_145504; NM_001346801
	NP_001275656; NP_001275657; NP_055877
	NP_001074683; NP_001333730
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.