PPT1

PPT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GRO
Identifiers
Aliases	PPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 1
External IDs	OMIM: 600722; MGI: 1298204; HomoloGene: 7488; GeneCards: PPT1; OMA:PPT1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	40,097,260 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	122,752,968 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lateral nuclear group of thalamus; ; retinal pigment epithelium; ; external globus pallidus; ; Pons; ; granulocyte; ; parotid gland; ; pars compacta; ; blood; ; pars reticulata;
	Top expressed in
	medial vestibular nucleus; ; deep cerebellar nuclei; ; seminiferous tubule; ; right kidney; ; pontine nuclei; ; dorsal tegmental nucleus; ; cerebellar cortex; ; median eminence; ; globus pallidus; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; palmitoyl hydrolase activity; hydrolase activity; palmitoyl-(protein) hydrolase activity; protein binding;
Cellular component	cytosol; Golgi apparatus; membrane; lysosomal lumen; membrane raft; lysosome; extracellular exosome; nucleus; extracellular region; synaptic vesicle; axon; extracellular space; dendrite; neuron projection; soma; synapse;
Biological process	negative regulation of neuron apoptotic process; positive regulation of pinocytosis; positive regulation of receptor-mediated endocytosis; lysosomal lumen acidification; response to stimulus; neuron development; negative regulation of apoptotic process; receptor-mediated endocytosis; nervous system development; lipid catabolic process; brain development; membrane raft organization; protein catabolic process; sphingolipid catabolic process; negative regulation of cell growth; protein transport; protein depalmitoylation; pinocytosis; regulation of synapse structure or activity; visual perception; fatty-acyl-CoA biosynthetic process; chemical synaptic transmission; lysosome organization; neurotransmitter secretion; grooming behavior; associative learning; adult locomotory behavior; regulation of phospholipase A2 activity; cellular macromolecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5538
	19063
	ENSG00000131238
	ENSMUSG00000028657
	P50897
	O88531
	NM_000310; NM_001142604; NM_001363695
	NM_008917
	NP_000301; NP_001136076; NP_001350624
	NP_032943
	Wikidata
View/Edit Human	View/Edit Mouse

Palmitoyl-protein thioesterase 1 (PPT-1), also known as palmitoyl-protein hydrolase 1, is an enzyme that in humans is encoded by the PPT1 gene.