PQBP1

PQBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BWQ, 4BWS, 4CDO
Identifiers
Aliases	PQBP1, MRX2, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS, polyglutamine binding protein 1
External IDs	OMIM: 300463; MGI: 1859638; HomoloGene: 4172; GeneCards: PQBP1; OMA:PQBP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	48,903,402 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,765,508 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; anterior pituitary; ; body of pancreas; ; monocyte; ; body of stomach; ; tendon of biceps brachii;
	Top expressed in
	saccule; ; otic placode; ; external carotid artery; ; internal carotid artery; ; superior cervical ganglion; ; otic vesicle; ; fossa; ; suprachiasmatic nucleus; ; motor neuron; ; condyle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; protein binding; ribonucleoprotein complex binding; double-stranded DNA binding;
Cellular component	neuronal ribonucleoprotein granule; cytoplasmic stress granule; nucleus; nucleoplasm; cytoplasm; cytosol; nuclear speck;
Biological process	regulation of transcription, DNA-templated; mRNA processing; transcription, DNA-templated; regulation of dendrite morphogenesis; regulation of RNA splicing; RNA splicing; neuron projection development; alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; activation of innate immune response; positive regulation of defense response to virus by host; positive regulation of type I interferon production; defense response to virus; cellular response to exogenous dsRNA; immune system process; innate immune response; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	10084
	54633
	ENSG00000102103
	ENSMUSG00000031157
	O60828
	Q91VJ5
NM_001032381; NM_001032382; NM_001032383; NM_001032384; NM_001032385;
	NM_001167989; NM_001167990; NM_001167992; NM_005710; NM_144494; NM_144495
	NM_001252528; NM_001252529; NM_019478
NP_001027553; NP_001027554; NP_001027555; NP_001027556; NP_001161461;
	NP_001161462; NP_001161464; NP_005701; NP_652766
	NP_001239457; NP_001239458; NP_062351
	Wikidata
View/Edit Human	View/Edit Mouse

Polyglutamine-binding protein 1 (PQBP1) is a protein that in humans is encoded by the PQBP1 gene.

Polyglutamine binding protein-1, which was identified as a binding protein to the polyglutamine tract sequence, is an evolutionally conserved protein expressed in various tissues including developmental and adult brains or mesodermal tissues. In cells, PQBP1 is dominantly located in the nucleus but also in the cytoplasm dependently on the cell type and stress conditions. PQBP1 has recently been found to play a role in the innate immune response of dendritic cells.

It should be of note that PQBP1 has no relationship with QBP1, an artificial synthetic peptide.