Puerto Rico Highway 52
| Ruta 52 | ||||
| Autopista Luis A. Ferré | ||||
PR-52 highlighted in red  | ||||
| Route information | ||||
| Maintained by Metropistas | ||||
| Length | 108.5 km (67.4 mi) | |||
| Existed | 1968–present | |||
| Major junctions | ||||
| South end | PR-2 / PR-9 in Canas | |||
| North end | PR-1 / PR-18 in Monacillo Urbano | |||
| Location | ||||
| Country | United States | |||
| Territory | Puerto Rico | |||
| Municipalities | Ponce, Juana Díaz, Santa Isabel, Salinas, Cayey, Caguas, Trujillo Alto, San Juan | |||
| Highway system | ||||
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Puerto Rico Highway 52 (PR-52), a major toll road in Puerto Rico, is also known as Autopista Luis A. Ferré. It was formerly called Expreso Las Américas. It runs from PR-1 in southwest Río Piedras and heads south until it intersects with highway PR-2 in Ponce. At its north end, the short PR-18 continues north from PR-52 towards San Juan. This short segment is known as Expreso Las Américas, the only segment of the route still unofficially bearing this name, since PR-18 is officially named Roberto Sánchez Vilella Expressway. The combined route of PR-18 and PR-52 runs concurrent with the unsigned Interstate Highway PRI-1. Toll stations are located in San Juan, Caguas, Salinas, Juana Díaz, and Ponce.
- Puerto Rico Highway 52 by municipality
 - Heading south in Cayey
 - Heading north between Salinas and Cayey
 - Heading north near Santa Isabel