PRAME

PRAME
Identifiers
Aliases	PRAME, CT130, MAPE, OIP-4, OIP4, preferentially expressed antigen in melanoma, PRAME nuclear receptor transcriptional regulator
External IDs	OMIM: 606021; HomoloGene: 48404; GeneCards: PRAME; OMA:PRAME - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	22,559,361 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; testicle; ; gonad; ; endometrium; ; right adrenal cortex; ; left ovary; ; left adrenal gland; ; right ovary; ; left adrenal cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; retinoic acid receptor binding;
Cellular component	plasma membrane; nucleus; membrane; cytoplasm;
Biological process	negative regulation of cell differentiation; regulation of growth; cell differentiation; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell population proliferation; apoptotic process; negative regulation of retinoic acid receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23532
	n/a
	ENSG00000185686; ENSG00000275013
	n/a
	P78395
	n/a
NM_001291715; NM_001291716; NM_001291717; NM_001291719; NM_006115;
	NM_206953; NM_206954; NM_206955; NM_206956; NM_001318126; NM_001318127
	n/a
NP_001278644; NP_001278645; NP_001278646; NP_001278648; NP_001305055;
	NP_001305056; NP_006106; NP_996836; NP_996837; NP_996838; NP_996839
	n/a
	Wikidata
View/Edit Human

PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.