PRDM1

PRDM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DAL
Identifiers
Aliases	PRDM1, BLIMP1, PRDI-BF1, PR domain 1, PR/SET domain 1
External IDs	OMIM: 603423; MGI: 99655; HomoloGene: 925; GeneCards: PRDM1; OMA:PRDM1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	106,109,939 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	44,404,497 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; oral cavity; ; mucosa of pharynx; ; stromal cell of endometrium; ; rectum; ; skin of thigh; ; blood; ; vagina; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	gastrula; ; decidua; ; otic placode; ; zygote; ; otic vesicle; ; migratory enteric neural crest cell; ; lip; ; skin of back; ; esophagus; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; promoter-specific chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin DNA binding;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	germ cell development; trophoblast giant cell differentiation; cardiac septum development; cell fate commitment; heart valve development; regulation of transcription, DNA-templated; ventricular septum development; intestinal epithelial cell development; positive regulation of B cell differentiation; embryonic placenta development; in utero embryonic development; negative regulation of transcription by RNA polymerase II; post-embryonic development; coronary vasculature development; negative regulation of gene expression; morphogenesis of a branching structure; transcription, DNA-templated; negative regulation of lipopolysaccharide-mediated signaling pathway; aorta development; methylation; positive regulation of gene expression; maternal placenta development; regulation of cell population proliferation; artery morphogenesis; eye photoreceptor cell development; sebum secreting cell proliferation; negative regulation of B cell proliferation; adaptive immune response; immune system process; regulation of natural killer cell differentiation; regulation of extrathymic T cell differentiation; innate immune response; regulation of NK T cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	639
	12142
	ENSG00000057657
	ENSMUSG00000038151
	O75626
	Q60636
	NM_001198; NM_182907
	NM_007548
	NP_001189; NP_878911
NP_031574; NP_001392858; NP_001392859; NP_001392860; NP_001392861;
	NP_001392862; NP_001392863; NP_001392864; NP_001392865
	Wikidata
View/Edit Human	View/Edit Mouse

PR domain zinc finger protein 1, or B lymphocyte-induced maturation protein-1 (BLIMP-1), is a protein in humans encoded by the gene PRDM1 located on chromosome 6q21. BLIMP-1 is considered a 'master regulator' of hematopoietic stem cells, and plays a critical role in the development of plasma B cells, T cells, dendritic cells (DCs), macrophages, and osteoclasts. Pattern Recognition Receptors (PRRs) can activate BLIMP-1, both as a direct target and through downstream activation. BLIMP-1 is a transcription factor that triggers expression of many downstream signaling cascades. As a fine-tuned and contextual rheostat of the immune system, BLIMP-1 up- or down-regulates immune responses depending on the precise scenarios. BLIMP-1 is highly expressed in exhausted T-cells – clones of dysfunctional T-cells with diminished functions due to chronic immune response against cancer, viral infections, or organ transplant.