PRDM12

PRDM12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EP0
Identifiers
Aliases	PRDM12, PFM9, HSAN8, PR domain 12, PR/SET domain 12
External IDs	OMIM: 616458; MGI: 2685844; HomoloGene: 10999; GeneCards: PRDM12; OMA:PRDM12 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	130,682,986 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,545,807 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; pericardium; ; globus pallidus; ; internal globus pallidus; ; jejunum; ; prefrontal cortex; ; Hypothalamus; ; hippocampal formation; ; temporal lobe; ; Mesencephalon;
	Top expressed in
	spinal ganglia; ; neural tube; ; trigeminal ganglion; ; ventricular zone; ; ganglion of neuraxis; ; glossopharyngeal ganglion; ; superior colliculus; ; septum of telencephalon; ; neural groove; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; metal ion binding; nucleic acid binding; histone methyltransferase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	neurogenesis; methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of histone H3-K9 dimethylation; sensory perception of pain; neuron projection development; detection of temperature stimulus involved in sensory perception of pain; positive regulation of histone H3-K9 methylation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	59335
	381359
	ENSG00000130711
	ENSMUSG00000079466
	Q9H4Q4
	A2AJ77
	NM_021619
	NM_001123362
	NP_067632
	NP_001116834
	Wikidata
View/Edit Human	View/Edit Mouse

PR domain zinc finger protein 12 is a protein that in humans is encoded by the PRDM12 gene. This gene is normally switched on during the development of pain-sensing nerve cells. People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). PRMD12 is a part of a larger domain that mediate histone methyltransferases. Enzymes target gene promoters in order to control gene expression.