PRDM9

PRDM9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IJD, 5EGB, 5EH2, 5EI9
Identifiers
Aliases	PRDM9, MEISETZ, MSBP3, PFM6, PRMD9, ZNF899, PR domain 9, PR/SET domain 9, KMT8B
External IDs	OMIM: 609760; MGI: 2384854; HomoloGene: 104139; GeneCards: PRDM9; OMA:PRDM9 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	23,528,093 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,564,354 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right testis; ; left testis; ; sural nerve; ; corpus callosum; ; mononuclear cell; ; monocyte; ; granulocyte; ; bone;
	Top expressed in
	neural layer of retina; ; granulocyte; ; muscle of thigh; ; zygote; ; lip; ; tail of embryo; ; spermatid; ; right kidney; ; morula; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; recombination hotspot binding; histone-lysine N-methyltransferase activity; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin DNA binding; histone methyltransferase activity (H3-K4 specific); DNA-binding transcription factor activity;
Cellular component	nucleoplasm; intracellular anatomical structure; nucleus; chromosome;
Biological process	meiotic gene conversion; positive regulation of reciprocal meiotic recombination; histone lysine methylation; methylation; regulation of transcription, DNA-templated; meiosis; transcription, DNA-templated; chromatin organization; regulation of transcription by RNA polymerase II; histone H3-K4 methylation;
	Sources:Amigo / QuickGO
Orthologs
	56979
	213389
	ENSG00000164256
	ENSMUSG00000051977
	Q9NQV7
	E9Q4V2
	NM_020227; NM_001310214; NM_001376900
	NM_144809; NM_001361436
	NP_001297143; NP_064612; NP_001363829
	NP_659058; NP_001348365
	Wikidata
View/Edit Human	View/Edit Mouse

PR domain zinc finger protein 9 is a protein that in humans is encoded by the PRDM9 gene. PRDM9 is responsible for positioning recombination hotspots during meiosis by binding a DNA sequence motif encoded in its zinc finger domain. PRDM9 is the only speciation gene found so far in mammals, and is one of the fastest evolving genes in the genome.