Prolargin

PRELP
Identifiers
Aliases	PRELP, MST161, MSTP161, SLRR2A, proline/arginine-rich end leucine-rich repeat protein, proline and arginine rich end leucine rich repeat protein
External IDs	OMIM: 601914; MGI: 2151110; HomoloGene: 2041; GeneCards: PRELP; OMA:PRELP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,491,352 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	133,849,152 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; right coronary artery; ; synovial joint; ; popliteal artery; ; ascending aorta; ; tibial arteries; ; pericardium; ; Descending thoracic aorta; ; left coronary artery; ; tibia;
	Top expressed in
	ankle; ; aortic valve; ; brown adipose tissue; ; white adipose tissue; ; right lung; ; calvaria; ; ascending aorta; ; sciatic nerve; ; right lung lobe; ; Epithelium of choroid plexus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular matrix; Golgi lumen; extracellular vesicle; lysosomal lumen; extracellular exosome; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	skeletal system development; keratan sulfate biosynthetic process; keratan sulfate catabolic process; axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5549
	116847
	ENSG00000188783
	ENSMUSG00000041577
	P51888
	Q9JK53
	NM_201348; NM_002725
	NM_054077
	NP_002716; NP_958505
	NP_473418
	Wikidata
View/Edit Human	View/Edit Mouse

Prolargin is a protein that in humans is encoded by the PRELP gene.

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.