PREPL

PREPL
Identifiers
Aliases	PREPL, prolyl endopeptidase-like, CMS22, prolyl endopeptidase like
External IDs	OMIM: 609557; MGI: 2441932; HomoloGene: 15481; GeneCards: PREPL; OMA:PREPL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	44,361,862 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,397,669 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; postcentral gyrus; ; pars compacta; ; lateral nuclear group of thalamus; ; external globus pallidus; ; Pons; ; pars reticulata; ; entorhinal cortex;
	Top expressed in
	ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; ventral tegmental area; ; pontine nuclei; ; medial geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; medial vestibular nucleus; ; inferior colliculi; ; central gray substance of midbrain;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	serine-type exopeptidase activity; peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cytoskeleton;
Biological process	proteolysis; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9581
	213760
	ENSG00000138078
	ENSMUSG00000024127
	Q4J6C6
	Q8C167
NM_001042385; NM_001042386; NM_001171603; NM_001171606; NM_001171613;
	NM_001171617; NM_006036; NM_001374275; NM_001374276; NM_001374277
	NM_001163622; NM_001163623; NM_001163624; NM_145984
NP_001035844; NP_001035845; NP_001165074; NP_001165077; NP_001165084;
	NP_001165088; NP_006027; NP_001361204; NP_001361205; NP_001361206
	NP_001157094; NP_001157095; NP_001157096; NP_666096
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene.

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM]