PREX1

PREX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QIK, 4YON, 5D3W, 5D3V, 5FI0, 5D27, 5D3Y, 5FI1, 5D3X
Identifiers
Aliases	PREX1, P-REX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
External IDs	OMIM: 606905; MGI: 3040696; HomoloGene: 10821; GeneCards: PREX1; OMA:PREX1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	48,827,999 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,555,752 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; blood; ; corpus callosum; ; C1 segment; ; granulocyte; ; ganglionic eminence; ; right lung; ; subthalamic nucleus; ; external globus pallidus; ; substantia nigra;
	Top expressed in
	granulocyte; ; decidua; ; lymph node; ; gastrula; ; mesenteric lymph nodes; ; thymus; ; membranous bone; ; trigeminal ganglion; ; tail of embryo; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; protein binding; enzyme binding; phospholipid binding; guanyl-nucleotide exchange factor activity;
Cellular component	membrane; growth cone; plasma membrane; dendritic shaft; perinuclear region of cytoplasm; cytoplasm; cytosol;
Biological process	intracellular signal transduction; neutrophil activation; regulation of dendrite development; neutrophil chemotaxis; reactive oxygen species metabolic process; regulation of actin filament polymerization; actin filament polymerization; positive regulation of GTPase activity; positive regulation of substrate adhesion-dependent cell spreading; T cell differentiation; regulation of Rho protein signal transduction; superoxide metabolic process; positive regulation of cell adhesion; negative regulation of protein kinase activity; positive regulation of cell migration; negative regulation of TOR signaling; positive regulation of apoptotic process; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57580
	277360
	ENSG00000124126
	ENSMUSG00000039621
	Q8TCU6
	Q69ZK0
	NM_020820
	NM_177782
	NP_065871
	NP_808450
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.