PREX2

PREX2
Identifiers
Aliases	PREX2, 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
External IDs	OMIM: 612139; MGI: 1923385; HomoloGene: 23523; GeneCards: PREX2; OMA:PREX2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	68,237,032 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	11,373,905 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; visceral pleura; ; corpus callosum; ; ventricular zone; ; parietal pleura; ; epithelium of colon; ; adipose tissue; ; subcutaneous adipose tissue; ; caudate nucleus;
	Top expressed in
	left lung lobe; ; lobe of cerebellum; ; cerebellar vermis; ; zygote; ; sciatic nerve; ; lateral septal nucleus; ; tail of embryo; ; otolith organ; ; right lung; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; plasma membrane; cytosol;
Biological process	adult locomotory behavior; phosphatidylinositol 3-kinase signaling; G protein-coupled receptor signaling pathway; regulation of Rho protein signal transduction; intracellular signal transduction; dendrite morphogenesis; positive regulation of GTPase activity; negative regulation of protein kinase activity; negative regulation of TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	80243
	109294
	ENSG00000046889
	ENSMUSG00000048960
	Q70Z35
	Q3LAC4
	NM_024870; NM_025170
	NM_001033636; NM_029525
	NP_079146; NP_079446
	NP_001028808; NP_083801
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.